Clinical Pharmacology
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Choosing an antiepileptic: Selecting drugs for older patients with epilepsy

After age 65, the incidence of epilepsy increases rapidly. Approximately 1.5% of Medicare recipients and 10% of nursing home residents are being treated with antiepileptic drugs (AEDs). The most commonly used AED is phenytoin, a first generation agent. Appropriate drug selection in this population is complicated by the fact that multiple comorbidity is commonplace.
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Herb-drug interactions

Interactions between saw palmetto and prescription medications

Patients over age 50 typically present with one chronic disease per decade. Each chronic disease typically requires long-term drug therapy, meaning most older patients require several drugs to maintain health. Simultaneously, use of complementary and alternative medicine (CAM) has increased in the United States in the last 20 years, reaching 36% in 2002; herbal medicine use accounts for approximately 22% of all CAM use.
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Pre-approval Feature

Focus On: Exubera An Orally inhaled insulin

Long-term glycemic control substantially reduces the risk of diabetes mellitus-related complications. Insulin is a mainstay in therapy in type 1 and later-stage type 2 diabetes mellitus. Although insulin is effective in controlling blood glucose and hemoglobin A1c concentrations, the need for subcutaneous injection can be a burden for patients, which can impact compliance. Exubera (Nektar Therapeutics/Pfizer/Sanofi-Aventis) is an inhaled insulin that has demonstrated results similar to conventional short-acting insulin products while also increasing overall patient satisfaction.
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Herb-drug interactions

Interactions between ginseng and prescription medications

Ginseng has been recommended for a wide variety of uses including amelioration of physical and mental performance, but there is little evidence of its efficacy. Evidence shows that it has some value in infection resistance, reducing stress, lowering cholesterol and blood sugar levels, and has a modest estrogen-like effect on women.
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Endocrinology

Pharmacologic options for the management of diabetic peripheral neuropathy

Diabetic peripheral neuropathy, one of the most common late complications of diabetes, is associated with decreased quality of life and increased morbidity. The pathophysiology of diabetic neuropathy (DN) is multifactorial, contributing to ischemic and painful events and neuronal damage.
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Industry Roundup

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